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#134 Most Followed Neuroscientist: The Effects of AI on Your Brain

Big Deal · Codie Sanchez — Emily MacGal · April 6, 2026 · Original

Most important take away

Frequent AI use for critical thinking tasks trains dependence rather than intelligence. An MIT study showed that people who used AI (versus Google or nothing) to write essays demonstrated decreased brain engagement and reduced critical thinking ability over time. The key distinction is that Google still requires you to evaluate multiple sources and synthesize your own conclusions, while AI does all the critical thinking for you.

Summary

Key Themes

1. Your brain constructs your entire experience of reality. This is not metaphorical — it is literal neuroscience. The classic kitten study (1970s) showed that kittens raised seeing only horizontal stripes could not perceive vertical objects like table legs. Color does not exist as a physical property; it is a construct the brain creates to distinguish wavelengths of light. People with body dysmorphia have measurably different brain activation patterns, meaning their brains literally construct a different image of themselves. The implication: if your brain constructs reality, you can change your brain to change what you experience.

2. AI is reducing critical thinking capacity. An MIT study compared essay writing using AI vs. Google vs. no assistance. AI users showed less brain engagement and decreased critical thinking over time. Google still requires evaluating multiple sources and forming your own conclusions. AI summarizes and decides for you, removing the critical thinking step entirely. Emily also shares her personal experience: she stopped having daily “life-changing realizations” during self-talk sessions when she started outsourcing those conversations to ChatGPT. She now avoids using AI for thinking and has returned to talking to herself.

3. Complaining physically damages your brain. Complaining, judging, and criticizing activate neuroplasticity in the wrong direction — they train your brain to look for more things to complain about. Chronic negativity leads to stress that can shrink the prefrontal cortex (the “boss” of the brain). Research shows there is no form of venting that is positive unless you reappraise the situation afterward. You must either tell a new story or decide on an action to take.

4. Discipline is nervous system regulation, not willpower. When you break promises to yourself, your brain loses trust in you, creating a state of internal dysregulation that others can literally feel. Brainwave synchronization research shows our neural patterns sync with the people around us. Chemical “chemo signals” from stress leak through the air and can be detected by others. This is why lack of discipline is unattractive — people can sense the dysregulation.

5. Being extreme and “all in” is neurologically optimal. Neuroplasticity depends on repetition over time and is enhanced by emotional intensity. When you are obsessed/devoted to a goal, your reticular activating system filters reality for opportunities related to that goal. Work-life balance produces balanced (mediocre) results. Periods of intense output followed by periods of rest are more effective than trying to balance everything simultaneously.

Actionable Insights

  • Stop using AI for thinking; use it only for building and execution. Reserve AI for monotonous tasks, coding, and organization. Do your own critical thinking, creative work, and self-reflection without AI assistance.
  • Practice self-talk daily. Talk to yourself like your best friend — out loud, during walks or drives. Ask yourself how you are feeling and why. This builds self-connection, creativity, and intuition that AI outsourcing destroys.
  • Reappraise after every complaint. When you catch yourself complaining, ask: “Am I reinforcing my current reality or creating a new one?” Then either reframe the situation or decide on an action.
  • Use the reticular activating system intentionally. Prime your brain by clearly defining what you want (in relationships, business, fitness, etc.). Your brain can only filter for opportunities it has been primed to recognize. Try picking a random object and noticing how often you see it — this demonstrates the power of priming.
  • Curate your inputs ruthlessly. Brainwave synchronization means the people you spend time with and the content you consume literally reshape your neural patterns. Cut off relationships and unfollow accounts that do not serve your goals. Automatic goal contagion means you subconsciously adopt the goals of those around you.
  • Use positive self-talk as a performance enhancer. Belief in yourself is shown to be more important than talent or intelligence. After every work session or workout, affirm yourself. This boosts dopamine and creates positive reinforcement loops.
  • Practice loving kindness meditation. Research shows it can lengthen telomeres (particularly in women) and reduce stress. Start by sending love to someone you care about, then acquaintances, then someone you are in conflict with.
  • Evaluate studies by looking at sample size and reading multiple studies (or meta-analyses) on the same topic. No single study is definitive. Every study has flaws because they are conducted by imperfect humans.

Chapter Summaries

Discipline, Attractiveness, and Nervous System Regulation

Discipline is not about forcing yourself — it is about looking out for your future self. When you follow through on your own word, your nervous system regulates and you build self-trust. Others can literally feel your nervous system state through brainwave synchronization and chemical signals. Studies show traits like self-control and reliability are among the most attractive qualities.

Brainwave Synchronization and Curating Your Environment

Neurons fire in ensemble patterns that look like waves. When two people communicate, their brainwaves sync up. This applies to physical relationships and virtual ones (social media). Automatic goal contagion means you subconsciously absorb the goals and focus of the people you are around. Curate both your social circle and your content feed accordingly.

Complaining Shrinks Your Brain

Negative thought patterns activate neuroplasticity in harmful directions, training the brain to seek more negativity. Chronic stress from negativity can shrink the prefrontal cortex. No form of venting is beneficial unless followed by reappraisal. The key question to ask yourself: “Am I reinforcing my current reality or creating a new one?”

Optimism, Longevity, and the Placebo Effect

A Harvard study of 70,000 women over decades found optimistic women lived 11-20% longer than pessimistic ones. Loving kindness meditation can lengthen telomeres. The placebo effect is a real neurological effect — your brain triggers biological changes in your body based on belief. A hotel cleaning staff study showed women told their work was exercise actually burned more calories.

Your Brain Constructs Reality

The kitten stripe experiment demonstrates that brains can only perceive what they have been wired to perceive. Color is a brain construct, not a physical property. Identity-based motivation theory shows your brain only allows you to imagine goals congruent with your current identity. To dream bigger, you must first shift your identity.

The Reticular Activating System and Priming

Of 11 million bits of information arriving per second, only about 50 reach conscious awareness. The reticular activating system acts as the filter. Priming your brain (through visualization, writing, or intention-setting) changes what the filter lets through. A study showed people who wrote about feeling powerful performed significantly better in job interviews than those who wrote about feeling powerless.

AI’s Effect on the Brain

MIT research shows AI use decreases critical thinking ability over time compared to Google or unaided work. AI removes the cognitive work of evaluating sources and forming conclusions. Emily’s personal experience confirms that outsourcing self-reflection to AI disrupted her creativity and intuition. She recommends using AI for building and execution tasks only, never for thinking.

Content Creation and Going All In

Emily’s content strategy is intuition-driven, not psychologically engineered. Her best-performing content comes from topics she is most energized about. She tests ideas by explaining them to her best friend — if she can make her understand and stay engaged, it works for the audience. Neuroplasticity favors intense, devoted focus over balanced moderation.